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Pain Recognition in Rodents.

Vanessa L Oliver1, Daniel S J Pang2

  • 1Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Animal Health Unit, VP Research, University of Calgary, 3280 Hospital Dr NW, Calgary, Alberta, T2N 4Z6, Canada.

The Veterinary Clinics of North America. Exotic Animal Practice
|November 19, 2022
PubMed
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Recent advances offer new pain assessment scales for rodents, crucial for biomedical research. However, challenges remain in applying these validated pain scales effectively in clinical settings.

Area of Science:

  • Veterinary Medicine
  • Animal Welfare Science

Background:

  • Over the past decade, there has been a significant increase in methods for recognizing and assessing pain in rodents.
  • Validated pain assessment scales have been developed, primarily driven by the needs of biomedical research.
  • Applying these rodent pain scales in a clinical environment presents unique challenges.

Purpose of the Study:

  • To provide an introduction to the validation process for pain assessment scales.
  • To review current methods for pain assessment in rodents, detailing their respective strengths and weaknesses.
  • To offer recommendations for the effective assessment of pain in a clinical setting.

Main Methods:

  • Review of existing literature on rodent pain assessment scales.
  • Analysis of validation methodologies for pain assessment tools.
Keywords:
AnalgesiaMouseNociceptionPainRat

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  • Comparative evaluation of current pain assessment techniques.

    • Main Results:

    • Numerous pain assessment methods and validated scales are now available for rodents.
    • Biomedical research has spurred the development of these tools.
    • Clinical application of rodent pain scales faces specific obstacles.

    Conclusions:

    • Pain assessment in rodents has advanced significantly, with validated scales available.
    • Translating these research tools to clinical practice requires careful consideration of their limitations.
    • Recommendations are provided to improve clinical pain assessment in rodents.