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Microbiome in Anxiety and Other Psychiatric Disorders
Norman M Spivak1, Jonathan Haroon2, Andrew Swenson2
1UCLA-Caltech Medical Scientist Training Program; Department of Psychiatry and Biobehavioral Sciences, DGSOM, UCLA, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA.
The Medical Clinics of North America
|November 19, 2022
Summary
Gut microbiota changes, known as dysbiosis, impact diseases beyond the gut. Research now links gut microbiome alterations to neuropsychiatric conditions like Parkinson's and Alzheimer's diseases.
Area of Science:
- Microbiology
- Neuroscience
- Medicine
Background:
- Gut microbiota composition and function are increasingly recognized as critical factors in health.
- Dysbiosis, an imbalance in gut microbial communities, has been associated with various pathological conditions.
- Early research primarily linked gut dysbiosis to gastrointestinal disorders.
Purpose of the Study:
- To explore the expanding understanding of the gut microbiome's role in disease.
- To highlight the connection between gut microbiome alterations and neuropsychiatric disorders.
- To synthesize evidence on the gut microbiome's influence beyond the gastrointestinal tract.
Main Methods:
- Literature review of studies investigating gut microbiota and disease.
- Analysis of research focusing on the gut microbiome's impact on neurological and psychiatric conditions.
- Synthesis of findings linking dysbiosis to specific diseases.
Main Results:
- Gut microbiota fluctuations significantly influence disease processes.
- Dysbiosis is associated with negative health outcomes.
- Emerging evidence demonstrates the gut microbiome's role in neuropsychiatric diseases, including Parkinson's, Alzheimer's, and multiple sclerosis.
Conclusions:
- The gut microbiome's influence extends far beyond the gastrointestinal system.
- Dysbiosis is a significant factor in the pathogenesis of various systemic diseases.
- Further research into the gut microbiome-brain axis is crucial for understanding and treating neuropsychiatric disorders.
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