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Related Concept Videos

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Articles linked to this work by shared authors, journal, and citation graph.

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How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Journal of hematology & oncology·2016
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Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia.

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Related Experiment Video

Updated: Aug 20, 2025

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Haploidentical transplants with a G-CSF/ATG-based protocol: Experience from China.

Zheng-Li Xu1, Xiao-Jun Huang1

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Blood Reviews
|November 20, 2022
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Summary

The Beijing Protocol, using granulocyte colony-stimulating factor (G-CSF) and antithymocyte globulin (ATG), advances haploidentical donor stem cell transplantation (haplo-SCT) by improving graft-versus-host disease (GvHD) prophylaxis.

Keywords:
ATGG-CSFHaploidentical

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Area of Science:

  • Hematology
  • Immunology
  • Transplantation

Background:

  • Haploidentical donor stem cell transplantation (haplo-SCT) has seen significant advancements.
  • Graft-versus-host disease (GvHD) remains a major challenge in haplo-SCT.
  • T-cell repletion strategies are crucial for successful haplo-SCT outcomes.

Purpose of the Study:

  • To review the incidence and mechanisms of GvHD in haplo-SCT.
  • To summarize the efficacy of the Beijing Protocol for GvHD prophylaxis.
  • To discuss strategies for optimizing GvHD prophylaxis and recent advances in the Beijing Protocol.

Main Methods:

  • Review of existing literature on haplo-SCT and the Beijing Protocol.
  • Analysis of GvHD incidence and prophylaxis strategies.
  • Focus on the roles of G-CSF and ATG in GvHD prevention.

Main Results:

  • The Beijing Protocol utilizes G-CSF and ATG for intensive GvHD prophylaxis.
  • G-CSF is proposed to induce T-cell tolerance and alter graft components.
  • ATG provides an immunoregulatory effect for prophylaxis.

Conclusions:

  • The Beijing Protocol offers a promising strategy for GvHD prophylaxis in haplo-SCT.
  • Understanding the mechanisms of G-CSF and ATG is key to optimizing outcomes.
  • Continued research and refinement of the Beijing Protocol are essential for advancing haplo-SCT.