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Updated: Aug 20, 2025

Reconstruction of 3-Dimensional Histology Volume and its Application to Study Mouse Mammary Glands
Published on: July 26, 2014
CT IMAGE RECONSTRUCTION ON A LOW DIMENSIONAL MANIFOLD
Wenxiang Cong1, Ge Wang1, Qingsong Yang1
1Biomedical Imaging Center, Department of Biomedical Engineering Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Abstract:
The patch manifold of a natural image has a low dimensional structure and accommodates rich structural information. Inspired by the recent work of the low-dimensional manifold model (LDMM), we apply the LDMM for regularizing X-ray computed tomography (CT) image reconstruction. This proposed method recovers detailed structural information of images, significantly enhancing spatial and contrast resolution of CT images. Both numerically simulated data and clinically experimental data are used to evaluate the proposed method. The comparative studies are also performed over the simultaneous algebraic reconstruction technique (SART) incorporated the total variation (TV) regularization to demonstrate the merits of the proposed method. Results indicate that the LDMM-based method enables a more accurate image reconstruction with high fidelity and contrast resolution.
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