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Bone/cartilage targeted hydrogel: Strategies and applications.

Hao Zhang1,2, Shunli Wu1,2,3,4, Weikai Chen1,2,3,4

  • 1Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Bioactive Materials
|November 21, 2022
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Summary

Bone-targeted hydrogels offer promising local treatment for bone diseases by utilizing specific binding sites. This review explores their construction strategies and applications, highlighting their potential in improving drug delivery and patient outcomes.

Keywords:
BoneBone diseaseCartilageHydrogelTarget therapy

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Orthopedics

Background:

  • Bone diseases significantly impact patient quality of life.
  • Bone-targeted biomaterials enhance drug efficacy and reduce side effects.
  • Existing research primarily focuses on micro/nano-materials, with limited exploration of bone-targeted hydrogels.

Purpose of the Study:

  • To review bone-targeted hydrogels based on their application environment, construction strategies, and disease applications.
  • To highlight the potential of locally targeted hydrogels for bone disease treatment.
  • To provide a reference for developing advanced bone-targeted hydrogels.

Main Methods:

  • Review of existing literature on bone-targeted hydrogels.
  • Analysis of hydrogel properties and targeting mechanisms.
  • Categorization of hydrogels by application, design, and therapeutic use.

Main Results:

  • Bone/cartilage extracellular matrix and bone cells offer binding sites for targeted hydrogels.
  • Microgels with targeting properties are a key strategy for hydrogel development.
  • Injectable hydrogel drug depots represent another viable approach.

Conclusions:

  • Bone-targeted hydrogels, particularly for local applications, show significant therapeutic promise.
  • Further development in hydrogel design can improve drug delivery for bone conditions.
  • Increased awareness of bone-targeted materials is crucial for advancing skeletal disease treatment.