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Updated: Aug 20, 2025

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Microfluidic-assisted fiber production: Potentials, limitations, and prospects.

Afshin Abrishamkar, Azadeh Nilghaz1, Maryam Saadatmand2

  • 1Institute for Frontier Materials, Deakin University, Waurn Ponds, Victoria 3216, Australia.

Biomicrofluidics
|November 21, 2022
PubMed
Summary

Microfluidic spinning offers precise control for fabricating diverse fibrous materials with tunable properties. This review highlights advances in microfluidic techniques for creating advanced fibers for applications in sensors, tissue engineering, and drug delivery.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Conventional fiber production methods lack precise control over fiber morphology and properties.
  • Microfluidics presents a controlled and efficient approach for engineered fiber spinning.
  • This technology enables low-speed synthesis for diverse applications.

Purpose of the Study:

  • To review recent advances in microfluidic technology for fabricating fibrous materials.
  • To summarize microfluidic platforms and materials used for fiber production.
  • To highlight applications and future perspectives of microfluidic-spun fibers.

Main Methods:

  • Review of microfluidic platforms (glass, polymers, metals, 3D printed).
  • Description of fiber production using various materials (alginate, gelatin, silk, collagen, chitosan).
  • Discussion of cross-linking agents and mechanisms.

Main Results:

  • Microfluidic spinning yields fibers with diverse morphologies (cylindrical, hollow, core-shell, etc.) and tunable diameters (submicrometer to hundreds of micrometers).
  • Tunable mechanical properties are achievable.
  • Fibers exhibit potential in sensors, tissue engineering scaffolds, and drug delivery systems.

Conclusions:

  • Microfluidic spinning is a versatile technology for producing advanced fibrous materials.
  • Significant potential exists for applications in biomedical and engineering fields.
  • Further research is needed to address current limitations and explore future possibilities.