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Intrathyroidal Thymic Carcinoma: A Retrospective Case Series Study
Jinhui Liang1, Mei Huang1, Helang Huang1
1Department of Otorhinolaryngology and Head & Neck Surgery, Hanzhong Central Hospital, Hanzhong, China.
Ear, Nose, & Throat Journal
|November 21, 2022
Summary
Intrathyroidal thymic carcinoma (ITC) is a rare thyroid tumor. Surgical resection combined with radiotherapy and chemotherapy offers a favorable prognosis, with no recurrence or metastasis observed in a 13-patient study.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Intrathyroidal thymic carcinoma (ITC) is an uncommon, low-grade malignant thyroid neoplasm.
- Limited understanding exists regarding its clinical characteristics and treatment strategies.
- This study aims to elucidate the clinicopathological features, treatment outcomes, and prognosis of ITC.
Purpose of the Study:
- To explore the clinicopathological features of Intrathyroidal thymic carcinoma (ITC).
- To analyze treatment modalities and patient prognosis for ITC.
- To provide diagnostic and therapeutic references for ITC.
Main Methods:
- Retrospective analysis of clinical, pathological, therapeutic, and prognostic data.
- Inclusion of 13 patients diagnosed with ITC.
- Review of treatment protocols including surgery, radiotherapy, and chemotherapy.
Main Results:
- The study included 13 patients (7 males, 6 females; average age 51.9 years).
- All patients underwent surgical resection followed by radiotherapy (60-66 Gy).
- Five patients with lymph node metastasis received adjuvant chemotherapy; all patients survived with no recurrence or metastasis during follow-up (median 66 months).
Conclusions:
- Diagnosis of ITC relies on pathological and immunohistochemical findings, notably CD5 positivity.
- Surgical resection is the primary treatment for ITC.
- Adjuvant radiotherapy and chemotherapy are recommended to minimize recurrence and metastasis risk.
