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Testosterone Therapy for Dropped Head Syndrome: A Case Report
Timothy J Felong1, Lucia L Balos2, Nicholas J Silvestri1
1Departments of Neurology and.
Journal of Clinical Neuromuscular Disease
|November 21, 2022
Summary
Dropped head syndrome (DHS) in a Hodgkin lymphoma survivor resolved with testosterone therapy. This case highlights a potential endocrine link to this rare neuromuscular condition.
Area of Science:
- Neurology
- Endocrinology
- Oncology
Background:
- Dropped head syndrome (DHS) is a rare condition characterized by impaired neck extension, leading to a chin-on-chest posture.
- DHS can be associated with various neurological and endocrine disorders, and has been observed in Hodgkin lymphoma (HL) survivors post-irradiation.
Observation:
- A 58-year-old male, a survivor of HL, presented with DHS and significant weakness in his neck extensor muscles.
- Diagnostic workup, including EMG and muscle biopsy, revealed mixed myopathic and neurogenic changes.
Findings:
- Conservative management for DHS proved ineffective.
- Low-normal testosterone levels were identified in the patient.
- Initiation of testosterone therapy led to a complete resolution of DHS symptoms within four months.
Implications:
- This case suggests a potential link between hypogonadism and DHS in HL survivors.
- Testosterone therapy may be a viable, non-surgical treatment option for selected DHS patients.
- Further research is warranted to explore the endocrine basis of DHS in cancer survivors.
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