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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: Aug 20, 2025

$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Medical Concerns in Orthobiologics Procedures.

Peter C Yeh¹, Prathap Jayaram²

¹Department of Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, TN, USA; Vanderbilt Stallworth Rehabilitation Hospital, 2201 Children's Way, Suite 1318, Nashville, TN 37212, USA.

Physical Medicine and Rehabilitation Clinics of North America

|November 21, 2022

Summary

This summary is machine-generated.

Orthobiologics offer significant treatment potential for sports medicine and pain management. Current evidence suggests they have a favorable safety profile with no consistent severe side effects or increased risks of disease transmission, immune reactions, or cancer.

Keywords:

Adipose tissue derivatives BMAC Medical concerns Orthobiologics PRP

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$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

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Area of Science:

Orthobiologics
Regenerative Medicine
Musculoskeletal Health

Background:

Orthobiologics are increasingly utilized in sports medicine, musculoskeletal disorder treatment, and pain management.
Understanding potential side effects and risks is crucial for clinical application.

Purpose of the Study:

To review the safety profile of orthobiologic treatments.
To identify potential adverse events associated with orthobiologics.

Main Methods:

Review of existing literature on orthobiologic treatments.
Analysis of reported side effects and patient outcomes.

Main Results:

Orthobiologics demonstrate considerable therapeutic potential across various medical fields.
No consistent severe side effects were observed.
No increased risks of transmissible disease, immune-modulated reactions, or oncologic processes were identified.

Conclusions:

Orthobiologics represent a promising treatment option with a generally safe profile.
Further research can continue to elucidate long-term safety and efficacy.