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Updated: Aug 20, 2025

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
Published on: August 1, 2020
An Evidence-Based Approach to Orthobiologics for Tendon Disorders
Andre Armando Abadin1, Jordan Pearl Orr1, Alexander Raphael Lloyd1
1Department of Sports, Spine and Musculoskeletal Medicine, Swedish Medical Center, 1600 E Jefferson Street, Suite 300, Seattle, WA 98122, USA.
Abstract:
Tendinopathy is a chronic injury that affects both the athletic and general population. Recalcitrant tendinopathy is both frustrating for patients and providers once typical conservative treatments have been exhausted. Current research in orthobiologics shows that they are safe and could improve pain and function in recalcitrant cases. Unfortunately, many studies show inconsistency in the content of the orthobiologic injectate and approach in treatment protocols. There are robust data to support the use of platelet-rich plasma for the treatment of recalcitrant common extensor tendinopathy and plantar fasciopathy, but high-quality random control trials are needed before drawing definitive conclusions for other tendinopathies.

