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Updated: Aug 20, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Clinical Trials That Have Informed the Modern Management of Breast Cancer
Laura K Krecko1, Meeghan A Lautner2, Lee G Wilke3
1Department of Surgery, University of Wisconsin Hospital and Clinics, 600 Highland Avenue K4/642, Madison, WI 53792, USA. Electronic address: https://twitter.com/LauraKrecko.
Abstract:
Randomized controlled trials have informed the historical evolution of breast cancer management, distilling operative and nonoperative treatments to achieve disease control and improve survival while maximizing quality of life and minimizing complications. The authors describe landmark trials investigating and influencing the following aspects of breast cancer care: extent of breast surgery; axillary management; neoadjuvant and adjuvant therapies; and selection of chemotherapy versus endocrine therapy via application of genomic assays.
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