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Related Concept Videos

Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

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Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine...
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Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

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Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
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Related Experiment Video

Updated: Aug 20, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Adnexal and Sebaceous Carcinomas.

Edward W Seger1, Brett C Neill2, Stanislav N Tolkachjov3

  • 1Division of Dermatology, University of Kansas Medical Center, Kansas City, KS, USA.

Dermatologic Clinics
|November 21, 2022
PubMed
Summary

Rare adnexal carcinomas and sebaceous neoplasms originate from skin glands. Differentiating these malignant neoplasms is crucial for appropriate treatment, workup, and prognosis, guiding clinical management.

Keywords:
AdnexalApocrineCarcinomaEccrineMohs micrographic surgerySebaceousSkin cancer

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Adnexal carcinomas and sebaceous neoplasms are rare malignant tumors.
  • These neoplasms arise from eccrine, apocrine, or pilosebaceous structures.
  • Accurate distinction is vital due to varied treatment, workup, and prognosis.

Purpose of the Study:

  • To provide a comprehensive review of rare adnexal and sebaceous neoplasms.
  • To discuss apocrine, eccrine, follicular, and sebaceous neoplasms.
  • To outline clinical presentation, histologic findings, and management.

Main Methods:

  • Literature review of adnexal and sebaceous neoplasms.
  • Synthesis of clinical, histologic, and management data.
  • Focus on rare malignant neoplasms of skin appendages.

Main Results:

  • Detailed review of apocrine, eccrine, follicular, and sebaceous neoplasms.
  • Description of characteristic clinical and histologic features for each neoplasm.
  • Summary of current management recommendations for these rare tumors.

Conclusions:

  • Distinguishing between adnexal carcinomas and sebaceous neoplasms is critical.
  • Understanding subtype-specific features aids in diagnosis and treatment.
  • This review provides a resource for managing these rare malignant neoplasms.