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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Gene Expression Profiles in Cutaneous Oncology.

Bo M Kitrell1, Elliot D Blue2, Alfredo Siller2

  • 1College of Medicine, University of Nebraska Medical Center, 985645 Nebraska Medical Center, Omaha, NE, USA.

Dermatologic Clinics
|November 21, 2022
PubMed
Summary

Gene expression profiles (GEPs) offer new hope for treating advanced skin cancers like melanoma and squamous cell carcinoma. These advanced diagnostic tools improve treatment strategies for better patient outcomes.

Keywords:
Cutaneous melanomaDiagnosticGene expression profile(s)Gene expression profilingPrognosticSquamous cell carcinoma

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Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Skin cancer, particularly locally advanced or metastatic disease, presents significant challenges with limited treatment options and poor prognoses.
  • Recent advancements in understanding cancer pathogenesis have been driven by the discovery of key genes involved in disease development.
  • Gene expression profiling (GEP) has emerged as a revolutionary tool in oncology, offering new avenues for diagnosis and prognosis.

Purpose of the Study:

  • To provide a comprehensive review of diagnostic and prognostic gene expression profiles (GEPs) developed for skin cancers.
  • To highlight the potential of GEPs in refining current diagnostic and prognostic strategies for squamous cell carcinoma and melanoma.
  • To discuss how GEPs can guide management and treatment decisions to improve patient care in skin cancer.

Main Methods:

  • Literature review of studies focusing on gene expression profiles in skin cancer.
  • Analysis of GEPs developed for diagnostic and prognostic applications in melanoma and squamous cell carcinoma.
  • Synthesis of information on the clinical utility and potential impact of GEPs in patient management.

Main Results:

  • GEPs have been identified that correlate with specific skin cancer subtypes and stages.
  • These GEPs show promise in differentiating between indolent and aggressive forms of squamous cell carcinoma and melanoma.
  • The development of GEPs is paving the way for more personalized treatment approaches in skin cancer.

Conclusions:

  • Gene expression profiles represent a significant advancement in the diagnosis and prognosis of skin cancer.
  • GEPs have the potential to revolutionize patient care by enabling more precise treatment selection and management strategies.
  • Further research and clinical integration of GEPs are crucial for realizing their full potential in combating skin cancer.