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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

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Candida albicans the main opportunistic pathogenic fungus in humans

Ignacio Uriel Macias-Paz1, Salvador Pérez-Hernández1, Alejandra Tavera-Tapia1

  • 1Faculty of Medicine "Dr. Alberto Romo Caballero", Autonomous University of Tamaulipas, Tampico (Tamaulipas), Mexico.

Revista Argentina De Microbiologia
|November 21, 2022
PubMed

Insights

Candida albicans, a common microbe, causes severe infections in immunocompromised individuals. This review explores its pathogenic mechanisms, host immune responses, and antifungal resistance strategies.

Area of Science:

  • Mycology
  • Immunology
  • Microbiology

Background:

  • Candida albicans is a human commensal and opportunistic pathogen.
  • It causes mucosal and systemic infections, particularly in immunocompromised patients.

Approach:

  • This review synthesizes current knowledge on Candida albicans interactions with host cells.
  • It details the fungal virulence factors and host immune responses.
  • Mechanisms of antifungal resistance are also examined.

Key Points:

  • C. albicans employs virulence factors like adhesins, invasins, enzymes, and biofilm formation for host cell adhesion, invasion, and damage.
  • The fungus triggers specific host immune responses through its antigens.
  • C. albicans exhibits sophisticated mechanisms to evade antifungal agents.

Conclusions:

  • Understanding Candida albicans pathogenesis and host interactions is crucial for managing infections.
  • Further research into antifungal resistance mechanisms is needed to improve treatment outcomes.
Keywords:
Candida albicansCandidiasisFactores de virulenciaVirulence factors

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