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Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment
Yun-Ting Chao1,2,3, Tzu-Yi Hong1,3, Ching-Ju Yang1,3
1Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Scientific Reports
|November 21, 2022
Summary
The brain-derived neurotrophic factor (BDNF) Met allele enhances olfactory identification and semantic memory engagement. This genetic variant may promote adaptive neural reorganization to improve olfactory capacity in healthy individuals.
Area of Science:
- Neurogenetics
- Olfactory Neuroscience
- Cognitive Neuroscience
Background:
- Human olfactory function exhibits significant variability.
- The neurogenetic underpinnings of this variability are not well understood.
- Brain-derived neurotrophic factor (BDNF) is implicated in neural plasticity and cognitive function.
Purpose of the Study:
- To investigate the relationship between the BDNF val66met polymorphism and olfactory network organization.
- To explore how genetic variations influence olfactory performance and neural activity.
- To elucidate the neurogenetic basis of individual differences in smell perception.
Main Methods:
- Recruited healthy volunteers.
- Assessed olfactory identification performance.
- Acquired resting-state functional neuroimaging data.
- Genotyped participants for the BDNF val66met polymorphism.
Main Results:
- The presence of the Met allele correlated with enhanced olfactory identification abilities.
- Met allele carriers showed increased engagement of the semantic memory system within the olfactory network.
- These effects were observed in an allele dosage-dependent manner.
Conclusions:
- The BDNF val66met polymorphism influences olfactory network organization and function.
- The Met allele may facilitate adaptive neural reorganization, enhancing olfactory capacity.
- This study provides insight into the neurogenetic factors shaping human olfaction.
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