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Updated: Aug 20, 2025

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
Published on: September 19, 2012
The value of a two-armed Bayesian response adaptive randomization trial
Byron J Gajewski1, Susan E Carlson2, Alexandra R Brown1
1Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.
Abstract:
We investigate the value of a two-armed Bayesian response adaptive randomization (RAR) design to investigate early preterm birth rates of high versus low dose of docosahexaenoic acid during pregnancy. Unexpectedly, the COVID-19 pandemic forced recruitment to pause at 1100 participants rather than the planned 1355. The difference in power between number of participants at the pause and planned was 87% and 90% respectively. We decided to stop the study. This paper describes how the RAR was used to execute the study. The value of RAR in two-armed studies is quite high and their use in the future is promising.
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