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Updated: Aug 20, 2025

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Perianal Paget's disease

Pilar Navajas Hernández1, Teresa Valdés Delgado1, Jesús Machuca Aguado2

  • 1Aparato Digestivo, Hospital Universitario Virgen Macarena, España.

Revista Espanola De Enfermedades Digestivas
|November 22, 2022
PubMed

Insights

Extramammary Paget's disease (EMPD) is rare and challenging to diagnose. This case highlights the importance of biopsy in identifying Paget cells in anal and gluteal lesions.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Extramammary Paget's disease (EMPD) is an uncommon intraepithelial malignancy.
  • Distinguishing primary EMPD from secondary involvement is critical for appropriate management.

Observation:

  • An 85-year-old male presented with an erythematous plaque in the anal and gluteal region.
  • The lesion's location and appearance prompted further investigation.

Findings:

  • A biopsy confirmed the presence of Paget cells within the plaque.
  • This histological finding is diagnostic of Paget's disease.

Implications:

  • Early and accurate diagnosis of EMPD is crucial for patient outcomes.
  • This case underscores the need for vigilance in evaluating anal and gluteal skin lesions.

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