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Related Experiment Video

Updated: Aug 20, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

9.5K

Biomimetic and Bioactive Small Diameter Tubular Scaffolds for Vascular Tissue Engineering.

Elisabetta Rosellini1, Niccoletta Barbani1, Luigi Lazzeri1

  • 1Department of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56122 Pisa, Italy.

Biomimetics (Basel, Switzerland)
|November 22, 2022
PubMed
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Researchers developed tubular scaffolds from a gelatin/gellan/elastin blend to mimic blood vessels. Functionalized with REDV peptide, these scaffolds promoted endothelial cell growth, showing promise for vascular tissue engineering.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • Vascular tissue engineering requires scaffolds that mimic native blood vessels and promote endothelialization.
  • Existing materials often lack the necessary biomimetic and bioactive properties for successful vascular regeneration.

Purpose of the Study:

  • To produce and characterize small-caliber, biomimetic, and bioactive tubular scaffolds for vascular tissue engineering.
  • To evaluate the potential of these scaffolds to enhance endothelialization.

Main Methods:

  • Tubular scaffolds were fabricated using a gelatin/gellan/elastin (GGE) blend via freeze-drying and cross-linking.
  • Scaffolds were functionalized with Gly-Arg-Gly-Asp-Ser-Pro (GRGSDP) or Arg-Glu-Asp-Val (REDV) bioactive peptides.
Keywords:
elastinendothelializationfunctionalizationgelatingellanpeptide

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Last Updated: Aug 20, 2025

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Micropatterning and Assembly of 3D Microvessels
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Micropatterning and Assembly of 3D Microvessels

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Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

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  • Comprehensive physicochemical, mechanical, functional, and biological characterizations were performed, including in vitro cell culture studies.

    • Main Results:

    • GGE scaffolds exhibited suitable porosity for cell infiltration and a dense outer surface to prevent bleeding.
    • Scaffolds demonstrated good hydrophilicity, elastic properties similar to natural vessels, and adequate suture retention strength.
    • REDV-functionalized scaffolds significantly enhanced endothelial cell adhesion and growth, while GRGDSP scaffolds supported fibroblast adhesion.

    Conclusions:

    • The developed GGE tubular scaffolds are biomimetic, bioactive, and possess favorable properties for vascular tissue engineering applications.
    • REDV peptide functionalization is particularly effective in promoting endothelialization, suggesting potential for improved vascular graft performance.