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Juvenile localized scleroderma: A single-centre experience from India
Ankur Kumar Jindal1, Sanjeev Handa2, Sathish Kumar Loganathan1
1Allergy Immunology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Journal of the European Academy of Dermatology and Venereology : JEADV
|November 22, 2022
Summary
Early systemic corticosteroids combined with methotrexate show better outcomes for juvenile localized scleroderma (JLS) than methotrexate alone. This study highlights treatment responses in Indian JLS patients.
Area of Science:
- Pediatric Rheumatology
- Dermatology
- Autoimmune Diseases
Background:
- Juvenile localized scleroderma (JLS) is a rare, chronic autoimmune condition affecting skin and underlying tissues.
- This study presents the largest single-center cohort of JLS patients from India.
Purpose of the Study:
- To analyze the clinical characteristics, laboratory findings, and management of JLS patients.
- To identify factors predicting treatment response in JLS.
Main Methods:
- Retrospective analysis of 84 JLS patients from pediatric dermatology and rheumatology clinics.
- Data collected included clinical profile, investigations, and treatment modalities.
Main Results:
- Linear scleroderma was the most common subtype (67.7%).
- Extracutaneous manifestations (ECMs) occurred in 16.6% of patients, including arthritis and brain abnormalities.
- Dexamethasone oral mini-pulse (OMP) and calcipotriol predicted good treatment response.
Conclusions:
- Early combination therapy with systemic corticosteroids and methotrexate appears more effective than methotrexate alone for JLS.
- Treatment strategies should consider individual patient profiles and potential ECMs.
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