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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Ejection Fraction Improvement Does Not Reflect Changes in Quality of Life Following Cardiac Resynchronization Therapy

Scott A Rizzi1, Michael Torre2, T Jared Bunch1

  • 1From the Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT.

Critical Pathways in Cardiology
|November 22, 2022
PubMed

Insights

Cardiac resynchronization therapy (CRT) improved ejection fraction (EF) in most heart failure patients. However, this EF improvement did not significantly correlate with enhanced health-related quality of life (HRQoL).

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Medical Device Technology

Background:

  • Cardiac resynchronization therapy (CRT) is known to improve ejection fraction (EF) and health-related quality of life (HRQoL) in patients with heart failure with reduced EF (HFrEF).
  • The relationship between the degree of EF improvement and the extent of HRQoL gains following CRT remains unclear.

Purpose of the Study:

  • To investigate whether improvements in HRQoL after CRT correlate with enhanced left-ventricular ejection fraction (EF) response in HFrEF patients.
  • To assess the association between EF response categories and changes in generic and HF-specific HRQoL measures.

Main Methods:

  • A cohort of 115 HFrEF patients who underwent CRT with pre- and post-CRT HRQoL assessments were included.
  • EF response was categorized as absent, modest (0%-19% increase), or significant (>20% increase).
  • Associations between EF response and generic (PROMIS) and HF-specific (KCCQ-12) HRQoL were examined.

Main Results:

  • A majority of patients (80%) showed modest to significant EF response post-CRT.
  • Significant improvements were observed in KCCQ-12, PROMIS fatigue, and PROMIS satisfaction scores across all EF response groups.
  • No significant association was found between the degree of EF improvement and HRQoL outcomes at one year.

Conclusions:

  • While CRT effectively improves EF in most HFrEF patients, the extent of EF improvement does not significantly correlate with gains in generic or HF-specific HRQoL.
  • Further research is needed to identify other factors that may influence HRQoL improvements after CRT.
Abstract

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