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Glycemic Variability in Patients With Stage II-III Colon Cancer Treated With Surgery and Adjuvant Chemotherapy
Natalie Rasmussen Mandolfo1, Ann M Berger1, Leeza A Struwe1
1University of Nebraska Medical Center.
Oncology Nursing Forum
|November 22, 2022
Summary
Patients with type 2 diabetes (T2D) exhibit higher glycemic variability post-surgery and during chemotherapy. Glycemic control is crucial for all colon cancer patients undergoing treatment.
Area of Science:
- Oncology
- Endocrinology
- Clinical Nursing
Background:
- Colon cancer treatment involves surgery and adjuvant chemotherapy, impacting patient health.
- Glycemic variability is a concern, particularly for patients with type 2 diabetes (T2D).
Purpose of the Study:
- To investigate glycemic variability in stage II-III colon cancer patients during and after treatment.
- To compare glycemic variability between patients with and without T2D.
Main Methods:
- Retrospective analysis of electronic health records from 58 patients with stage II-III colon cancer.
- Glycemic variability measured using standard deviation and coefficient of variation.
- Statistical analyses included Chi-square, Fisher's exact, Mann-Whitney U tests, and Spearman's correlation.
Main Results:
- Patients with T2D demonstrated higher glycemic variability post-surgery and during chemotherapy.
- Non-T2D patients showed a significant increase in glycemic variability during chemotherapy.
- Associations between glycemic variability and clinical factors varied by T2D status.
Conclusions:
- Continuous blood glucose monitoring is essential for all colon cancer patients, irrespective of T2D status.
- Patient education on glycemic control during cancer treatment is a nursing priority.
- Further research should focus on predictive models for glycemic variability and its impact on cancer outcomes.
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