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Multifunctional Superparticles for Magnetically Targeted NIR-II Imaging and Photodynamic Therapy
Yilin Liu1, Yuan Liang2,3,4, Pengpeng Lei2
1School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 22, 2022
Summary
Researchers developed smart UCNPs/Fe3O4 superparticles for cancer theranostics. These particles enable real-time imaging and targeted photodynamic therapy, showing significant tumor accumulation and elimination potential.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Oncology
Background:
- Theranostics, combining diagnostics and therapy, offers promise for cancer treatment.
- Developing multifunctional theranostic systems for on-demand applications remains a challenge.
Purpose of the Study:
- To create a modular, user-friendly method for assembling multifunctional nanoparticles.
- To develop UCNPs/Fe3O4 superparticles for integrated cancer theranostics.
Main Methods:
- A microemulsion-based method was used to assemble upconversion nanoparticles (UCNPs) and Fe3O4 nanoparticles into superparticles.
- In vivo studies utilized 808 nm excitation for NIR-II imaging and 980 nm excitation for photodynamic therapy (PDT).
- Magnetic targeting was employed using an external magnet to guide superparticles to tumors.
Main Results:
- The UCNPs/Fe3O4 superparticles demonstrated real-time NIR-II imaging and magnetic targeting capabilities.
- Superparticles showed enhanced tumor accumulation (≈6-fold higher) with magnetic targeting compared to non-targeted injection.
- Magnetic targeting combined with NIR laser irradiation resulted in significant tumor elimination via PDT.
Conclusions:
- The developed UCNPs/Fe3O4 superparticles offer a promising platform for targeted cancer theranostics.
- The modular assembly method provides a user-friendly approach to creating multifunctional nanomedicines.
- This system integrates imaging, magnetic targeting, and therapeutic capabilities for potential clinical applications.
