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Association Of Liver Fatty Acid Binding Protein With Acute Kidney Injury In Paediatric Patients After Cardiac Surgery

Muhammad Basharat Khan1, Tahira Naseem2, Haseen Dil Wazir3

  • 1Department of pathology, Ayub medical college Abbottabad.

Journal of Ayub Medical College, Abbottabad : JAMC
|November 22, 2022
PubMed

Insights

Urinary Liver fatty acid-binding protein (uL-FABP) can predict acute kidney injury (AKI) in children after heart surgery. Measuring uL-FABP levels at 4 hours offers early detection, aiding timely interventions to prevent AKI.

Area of Science:

  • Pediatric Cardiology
  • Nephrology
  • Biomarker Discovery

Background:

  • Acute kidney injury (AKI) is a frequent complication following cardiac surgery in children.
  • Urinary Liver fatty acid-binding protein (uL-FABP) shows promise as a biomarker for renal injury and recovery.
  • Early diagnosis of AKI is crucial for timely treatment and improved patient outcomes.

Purpose of the Study:

  • To evaluate uL-FABP as an early diagnostic biomarker for AKI in pediatric patients undergoing cardiac surgery.
  • To assess the potential of uL-FABP for monitoring renal status and guiding early therapeutic interventions.

Main Methods:

  • A descriptive study was conducted at Sheikh Zayed Hospital, Lahore, from 2015 to 2016.
  • Convenience sampling was used to select patients for analysis of blood and urine markers.
  • Levels of serum creatinine and urinary L-FABP (uL-FABP) were measured.

Main Results:

  • 11.4% of 88 patients developed AKI post-cardiac surgery.
  • Serum creatinine rose 24-48 hours post-surgery, while uL-FABP elevated at 4 hours.
  • An optimal uL-FABP cut-off of 269 ng/l demonstrated 80% sensitivity and 83.3% specificity for early AKI detection.

Conclusions:

  • uL-FABP is a potential early predictor of AKI in pediatric cardiac surgery patients.
  • Early detection of AKI using uL-FABP can facilitate prompt treatment strategies.
  • uL-FABP may serve as a valuable biomarker for renal health monitoring in this population.
Abstract

Keywords:
Acute kidney injury; Urinary Liver Fatty Acid Binding Protein;Cardiac surgery; Biomarker; Sensitivity; Specificity

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