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Related Experiment Video

Updated: Aug 20, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Subretinal abscess: causative pathogens, clinical features and management.

Beatrice Gallo1, Ilaria Testi2, Carlos Pavesio2,3

  • 1Uveitis Service, Moorfields Eye Hospital NHS Foundation Trust, City Road, London, EC1V 2PD, UK. beatricegallo.bg@gmail.com.

Journal of Ophthalmic Inflammation and Infection
|November 22, 2022
PubMed
Summary
This summary is machine-generated.

This review of endogenous subretinal abscess (SRA) found that systemic antibiotics are crucial. Combined systemic and local treatments, often including vitrectomy, are the most common strategies for SRA management.

Keywords:
Endogenous endophthalmitisSubretinal abscessSystemic antibioticsTherapeutic strategy

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Retinal Surgery

Background:

  • Endogenous subretinal abscess (SRA) is a rare but serious intraocular infection.
  • Understanding the characteristics and treatment outcomes of SRA is crucial for effective patient management.

Purpose of the Study:

  • To conduct a literature review on endogenous subretinal abscess (SRA).
  • To analyze patient demographics, causative pathogens, clinical features, and treatment strategies for SRA.

Main Methods:

  • Literature search using terms 'subretinal abscess', 'chorio-retinal abscess', and 'choroidal abscess'.
  • Analysis of 122 identified patient cases, categorized into those with and without systemic infective foci.

Main Results:

  • Identified 122 patients with SRA; 20 had no systemic foci, 102 had systemic foci.
  • Common pathogens included Aspergillus, Nocardia, Mycobacterium Tuberculosis, and Klebsiella.
  • Reduced vision, pain, and redness were primary symptoms. Final visual acuity was significantly better in patients with systemic foci (p=0.003).
  • Diabetes and immunosuppression were key predisposing factors.
  • Combined systemic/intravitreal antibiotics and vitrectomy were common treatments.

Conclusions:

  • No established guidelines exist for SRA treatment.
  • Systemic broad-spectrum antibiotic treatment is paramount for SRA.
  • Combination therapy (systemic and local) is the most frequent approach.