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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
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NK cell therapy in relapsed refractory multiple myeloma.
Elham Roshandel1, Haniyeh Ghaffari-Nazari2, Mozhdeh Mohammadian3
1Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Immunology (Orlando, Fla.)
|November 22, 2022
Summary
Natural killer (NK) cell therapy shows promise for treating relapsed/refractory multiple myeloma (RR/MM). This approach leverages NK cells
Area of Science:
- Immunology
- Oncology
- Cell Therapy
Background:
- Adoptive cell therapy has advanced cancer immunotherapy, yet relapsed/refractory multiple myeloma (RR/MM) remains challenging.
- Natural killer (NK) cells possess inherent cytotoxic activity against myeloma cells and do not cause graft-versus-host disease.
Purpose of the Study:
- To review NK cell activity within the multiple myeloma (MM) microenvironment.
- To explore various NK cell-based therapeutic strategies for MM patients.
Main Methods:
- Review of scientific literature on NK cell function and therapeutic applications in MM.
- Discussion of ex vivo expanded/activated NK cells, NK cell lines, and chimeric antigen receptor (CAR)-NK cells.
- Consideration of large-scale, Good Manufacturing Practices (GMP) production of NK cells.
Main Results:
- NK cells demonstrate potent anti-myeloma cytotoxic activity.
- NK cell therapies, including autologous and allogeneic approaches, are being developed.
- Novel cell products like CAR-NK cells offer potential off-the-shelf treatments.
Conclusions:
- NK cell therapy is a promising strategy for managing RR/MM.
- Ongoing research focuses on optimizing NK cell expansion and novel therapeutic modalities.
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