Related Experiment Video
Updated: Aug 20, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
Metastatic Breast Cancer Presenting as Acute Appendicitis
David T Khalil1, Kellee Slater2, Caroline Cooper3
1Medicine, Queensland Health, Brisbane, AUS.
Abstract:
Breast cancer is one of the most commonly diagnosed cancers in Australia. With the development in screening, diagnosis, and treatment, people are living longer with metastatic disease of the breast. This malignancy commonly metastasizes to the lung, brain, bone, and liver. However, due to the increased survival of patients living with breast cancer, metastases may present with complications that have not been seen before. We describe a case of a 55-year-old female with a background of metastatic breast cancer to the brain who presented to the emergency department with acute appendicitis. At surgery, a malignant mass was found in the cecum obstructing the appendix, and histopathology revealed metastatic breast cancer.
Related Concept Videos
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Acute Pancreatitis II: Clinical Manifestations and Management
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

