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Daptomycin-Induced Eosinophilic Pneumonia Mimicking Multifocal Pneumonia
Randa Abd Algayoum1, Ahmed Elsherif1,2, Zarak H Khan1
1Internal Medicine, St. Mary Mercy Hospital, Livonia, USA.
Cureus
|November 23, 2022
Summary
A 71-year-old female developed acute eosinophilic pneumonia (AEP) after treatment with daptomycin. Prompt diagnosis and treatment with steroids led to a full recovery, highlighting the importance of recognizing drug-induced AEP.
Area of Science:
- Pulmonology
- Pharmacology
- Infectious Diseases
Background:
- Acute eosinophilic pneumonia (AEP) is a severe lung condition.
- Daptomycin is an antibiotic used for resistant infections.
- Drug-induced AEP can mimic other lung diseases, delaying diagnosis.
Observation:
- Chest imaging revealed bilateral opacities, and labs showed peripheral eosinophilia.
- Bronchoalveolar lavage and lung biopsy confirmed acute eosinophilic pneumonia (AEP).
Findings:
- Daptomycin-induced AEP presented similarly to community-acquired pneumonia, highlighting a diagnostic challenge.
- Prompt discontinuation of daptomycin and initiation of corticosteroids resulted in rapid clinical improvement.
Implications:
- This case underscores the importance of considering drug-induced lung injury, specifically daptomycin-induced AEP, in patients with new-onset pulmonary symptoms.
- Timely diagnosis and management of daptomycin-induced AEP are critical for favorable patient outcomes and preventing severe morbidity.
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