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Updated: Aug 20, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Fast Compressive Raman Imaging of Polymorph Molecules and Excipients in Pharmaceutical Tablets
Clément Grand1, Camille Scotté1, Hervé Rigneault1
1Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France.
Abstract:
We implement a near-infrared (NIR) version of compressive Raman imaging that incorporates a digital micromirror device (DMD) and a single-pixel detector for fast chemometric analysis and microscopic imaging. The NIR compressive Raman system is successfully used to detect and image active pharmaceutical ingredients exhibiting polymorphism within compact pharmaceutical tablets. We report the chemical imaging of a mixture of two clopidogrel polymorphs and three excipients in solid tablets with a pixel dwell time of 2.5 ms (0.5 ms per species). These results open the road to fast pharmaceutical tablet quality control imaging using compressive Raman technology.
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