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Efficacy of chlorhexidine in advanced performance technology formulation in decolonizing the skin using Candida auris

Mohammed Elshaer1, Janet Herrada2, Ahmed Gamal2

  • 1Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Department of Dermatology, Case Western Reserve University, Cleveland, OH.

American Journal of Infection Control
|November 23, 2022
PubMed

Insights

Candida auris infections are rising. A new chlorhexidine formulation (APT-CH) effectively reduced fungal presence on skin, offering a potential strategy against this resistant fungus.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Candida auris is an emerging fungal pathogen causing concern due to its multidrug resistance.
  • This yeast's capacity for skin colonization presents a risk for infection development.
  • Effective methods to decrease skin fungal load are crucial for infection control.

Purpose of the Study:

  • To evaluate the efficacy of a novel chlorhexidine formulation in reducing skin fungal burden.

Main Methods:

  • A new chlorhexidine formulation, Advanced Performance Technology-Chlorhexidine (APT-CH), was tested.
  • Effectiveness was compared against untreated controls.

Main Results:

  • APT-CH demonstrated significantly greater effectiveness in reducing skin fungal burden compared to controls.
  • The formulation showed promise in managing Candida auris colonization.

Conclusions:

  • The Advanced Performance Technology formulation of chlorhexidine is a promising agent for reducing skin fungal burden.
  • Further research is warranted to explore its clinical applications and long-term efficacy.
Keywords:
APT formulationSkin decolonization

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