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Updated: Aug 20, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Testing for a Change in Mean After Changepoint Detection
Sean Jewell1, Paul Fearnhead2, Daniela Witten3
1Department of Statistics, University of Washington, Seattle, USA.
Abstract:
While many methods are available to detect structural changes in a time series, few procedures are available to quantify the uncertainty of these estimates post-detection. In this work, we fill this gap by proposing a new framework to test the null hypothesis that there is no change in mean around an estimated changepoint. We further show that it is possible to efficiently carry out this framework in the case of changepoints estimated by binary segmentation and its variants, ℓ 0 segmentation, or the fused lasso. Our setup allows us to condition on much less information than existing approaches, which yields higher powered tests. We apply our proposals in a simulation study and on a dataset of chromosomal guanine-cytosine content. These approaches are freely available in the R package ChangepointInference at https://jewellsean.github.io/changepoint-inference/.
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