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Gut microbial response to host metabolic phenotypes.

Jinliang Hou1, Jianguo Xiang1, Deliang Li1

  • 1College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

Frontiers in Nutrition
|November 24, 2022
PubMed
Summary
This summary is machine-generated.

Gut microbes significantly influence host metabolic phenotypes by altering metabolism, physiology, and immunity. Understanding these gut microbiota interactions offers new strategies for preventing and treating metabolic diseases.

Keywords:
disease controlgut microbiomemetabolic phenotypemicrobial metabolitesnutrient metabolism

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Area of Science:

  • Microbiology
  • Metabolomics
  • Human Physiology

Background:

  • Biological metabolic phenotypes are objectively recognized and influenced by gut microbes.
  • Gut microbiota impacts host metabolism, physiology, and immunity via population structure, metabolites, and gene expression.
  • Research focuses on identifying gut microbiota factors linked to host metabolic phenotypes for disease treatment.

Purpose of the Study:

  • To review the relationship between gut microbes and host metabolic phenotypes.
  • To summarize current research on gut microbiota's role in carbohydrate, amino acid, lipid, and nucleic acid metabolism.
  • To explore potential therapeutic strategies targeting gut microbes for metabolic diseases.

Main Methods:

  • Literature review of studies on gut microbiota and host metabolic phenotypes.
  • Analysis of metabolic intermediates and mechanisms of action.
  • Synthesis of latest research findings and treatment strategies.

Main Results:

  • Gut microbes play a crucial role in host metabolic processes.
  • Specific gut microbial compositions and metabolites are associated with distinct metabolic phenotypes.
  • Interventions targeting gut microbiota show promise for metabolic disease management.

Conclusions:

  • Comprehensive understanding of gut microbe-host metabolic phenotype interactions is essential.
  • Precise modulation of gut microbiota represents a future therapeutic strategy for metabolic diseases.
  • Further research is needed to fully elucidate these complex relationships and develop effective treatments.