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Updated: Aug 20, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Intrinsic brain functional connectivity patterns in alcohol use disorder.

Nasim Maleki^1,2, Kayle S Sawyer^2,3,4,5, Sarah Levy⁶

¹Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

Brain Communications

|November 24, 2022

Summary

Individuals with alcohol use disorder show altered brain connectivity patterns. These changes in intrinsic functional connectivity may indicate persistent abnormalities or compensatory mechanisms related to the disorder.

Keywords:

alcohol use disorder fMRI functional connectivity

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Area of Science:

Neuroscience
Neuroimaging
Addiction Research

Background:

Alcohol use disorder (AUD) is linked to significant brain damage.
Understanding the neural underpinnings of AUD is crucial for effective treatment.
Intrinsic functional connectivity alterations may underlie cognitive deficits in AUD.

Purpose of the Study:

To compare static and dynamic functional connectivity in individuals with and without a history of alcohol use disorder.
To identify specific brain networks affected by alcohol use disorder.
To explore the relationship between connectivity changes, sobriety duration, and drinking severity.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was used.
Static and dynamic independent component analysis (ICA) were applied to fMRI data.
Neuropsychological assessments were conducted on 55 participants (23 with AUD, 32 controls).

Main Results:

Significant differences in static functional connectivity were found in the default mode, attention, frontoparietal, frontal cortical, and cerebellar networks.
Dynamic functional connectivity analyses revealed distinct temporal differences in reward, sensorimotor, and frontal cortical networks.
Specific connectivity patterns correlated with sobriety length and drinking severity.

Conclusions:

Findings suggest dysregulation in cortico-basal ganglia-thalamo-cortical loops in individuals with a history of alcohol use disorder.
Observed abnormalities may represent persistent network damage, compensatory processes, or a predisposition to AUD.
These insights contribute to understanding the persistent neurological impact of alcohol use disorder.