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Related Experiment Video

Updated: Aug 20, 2025

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

Published on: January 6, 2010

Development and evaluation of a variable, miniaturized oxygenator for various test methods.

Jutta Arens^1,2, Lotte Schraven², Andreas Kaesler²

¹Engineering Organ Support Technologies Group, Department of Biomechanical Engineering, Faculty of Engineering Technology, University of Twente, Enschede, The Netherlands.

Artificial Organs

|November 24, 2022

Summary

Researchers developed a novel, customizable oxygenator for Extracorporeal Membrane Oxygenation (ECMO) research. This cost-effective device ensures homogeneous blood flow and efficient gas exchange, proving comparable to commercial options.

Keywords:

adaptable extracorporeal lung assist gas exchange hemocompatibility hemolysis oxygenator variable

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Last Updated: Aug 20, 2025

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Area of Science:

Biomedical Engineering
Cardiopulmonary Support Systems

Background:

Extracorporeal membrane oxygenation (ECMO) is vital for severe respiratory failure but faces challenges like thrombus formation and reduced gas exchange.
Current commercial oxygenators may not suit all research needs, necessitating custom solutions for optimization studies.

Purpose of the Study:

To design and validate a laboratory-manufacturable, customizable oxygenator for ECMO research.
To ensure the new oxygenator meets criteria for homogeneous blood flow, low pressure drop, and adaptability.

Main Methods:

Designed an oxygenator prioritizing homogeneous flow, low pressure drop, lab manufacturability, variable membrane area, and cost-efficiency.
Compared the novel oxygenator against a commercial device, evaluating hemocompatibility, gas transfer, and pressure drop.

Main Results:

The new oxygenator demonstrated sufficient hemocompatibility with no significant difference in blood cell damage compared to commercial devices.
It proved easily manufacturable in the lab, adaptable to various membrane configurations, and reusable for analysis.
The design supports numerical simulations and offers variable membrane area sizing.

Conclusions:

The developed oxygenator is a valuable, versatile tool for experimental and numerical research aimed at optimizing ECMO systems.
Its design facilitates diverse research applications, including blood, numerical simulation, and membrane studies.