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Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

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Slippery Epidural ECoG Electrode for High-Performance Neural Recording and Interface.

Md Eshrat E Alahi¹, Yonghong Liu¹, Sara Khademi^1,2

¹The Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

|November 24, 2022

Summary

This summary is machine-generated.

A novel slippery liquid-infused porous surface (SLIPS) coating for epidural electrocorticography (ECoG) electrodes reduces noise and improves biocompatibility for chronic neural monitoring in neurodegenerative diseases.

Keywords:

ECoG electrode Pt-gray nanocone neural interface slippery coating surface modification

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Area of Science:

Biomedical Engineering
Materials Science
Neuroscience

Background:

Chronic implantation of epidural electrocorticography (ECoG) electrodes causes dural thickening and fibrosis, compromising long-term neural recording.
This tissue response is a major challenge for monitoring neurodegenerative diseases using ECoG.

Purpose of the Study:

To develop a Slippery Liquid-Infused Porous Surface (SLIPS) coating for flexible ECoG electrodes.
To enhance chronic neural interface performance by reducing tissue реакции and improving signal quality.

Main Methods:

Fabrication of ECoG electrodes on a polyimide substrate with a platinum-gray porous nanocone structure.
Infusion of silicone oil into the porous structure to create the SLIPS coating.
Electrochemical impedance spectroscopy, equivalent circuit modeling, cytotoxicity testing, and acute in vivo neural recording in a rat model.

Main Results:

The SLIPS coating exhibited a low impedance of 4.68 kΩ, suitable for neural recording.
Cytotoxicity studies confirmed the biocompatibility of the coating for human implantation.
In vivo recordings demonstrated a significant reduction in noise (nearly 50%), enhancing signal clarity.

Conclusions:

The developed SLIPS coating is biocompatible and effectively reduces noise in neural recordings.
This technology offers a promising solution for improving the longevity and efficacy of chronic ECoG interfaces for neurodegenerative disease monitoring.