Slippery Epidural ECoG Electrode for High-Performance Neural Recording and Interface.
Md Eshrat E Alahi1, Yonghong Liu1, Sara Khademi1,2
1The Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Biosensors
|November 24, 2022
Summary
A novel slippery liquid-infused porous surface (SLIPS) coating for epidural electrocorticography (ECoG) electrodes reduces noise and improves biocompatibility for chronic neural monitoring in neurodegenerative diseases.
Area of Science:
- Biomedical Engineering
- Materials Science
- Neuroscience
Background:
- Chronic implantation of epidural electrocorticography (ECoG) electrodes causes dural thickening and fibrosis, compromising long-term neural recording.
- This tissue response is a major challenge for monitoring neurodegenerative diseases using ECoG.
Purpose of the Study:
- To develop a Slippery Liquid-Infused Porous Surface (SLIPS) coating for flexible ECoG electrodes.
- To enhance chronic neural interface performance by reducing tissue реакции and improving signal quality.
Main Methods:
- Fabrication of ECoG electrodes on a polyimide substrate with a platinum-gray porous nanocone structure.
- Infusion of silicone oil into the porous structure to create the SLIPS coating.
- Electrochemical impedance spectroscopy, equivalent circuit modeling, cytotoxicity testing, and acute in vivo neural recording in a rat model.
Main Results:
- The SLIPS coating exhibited a low impedance of 4.68 kΩ, suitable for neural recording.
- Cytotoxicity studies confirmed the biocompatibility of the coating for human implantation.
- In vivo recordings demonstrated a significant reduction in noise (nearly 50%), enhancing signal clarity.
Conclusions:
- The developed SLIPS coating is biocompatible and effectively reduces noise in neural recordings.
- This technology offers a promising solution for improving the longevity and efficacy of chronic ECoG interfaces for neurodegenerative disease monitoring.
