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Related Experiment Video

Updated: Aug 20, 2025

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

A rare, giant, lateral intraventricular gliosarcoma.

Ho Xuan Tuan¹, Nguyen Minh Duc²

¹Department of Medical Imaging, University of Medical Technology and Pharmacy, Da Nang, Vietnam.

Radiology Case Reports

|November 25, 2022

Summary

Gliosarcoma, a rare glioblastoma subtype with distinct glial and sarcomatous tissues, can occur in the brain's supratentorial region. This case highlights a giant intraventricular gliosarcoma in a child, emphasizing its consideration in pediatric intraventricular tumor diagnoses.

Keywords:

Gliosarcoma Intraventricular tumor Magnetic resonance imaging

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Published on: April 21, 2014

Area of Science:

Neuro-oncology
Pediatric Pathology
Radiology

Background:

Gliosarcoma is a rare, biphasic glioblastoma subtype characterized by distinct glial and sarcomatous components.
It typically presents as a supratentorial tumor, posing diagnostic challenges due to its histological heterogeneity.

Observation:

A rare case of a giant left intraventricular gliosarcoma is presented in a 1-year-old male infant.
Magnetic resonance imaging revealed a supratentorial tumor with imaging features mimicking choroid plexus carcinoma.

Findings:

Histopathological examination confirmed the diagnosis of gliosarcoma.
The tumor's intraventricular location and biphasic nature were key diagnostic features.

Implications:

Gliosarcoma should be included in the differential diagnosis for pediatric intraventricular tumors, especially those with radiological similarities to choroid plexus carcinoma.
This case underscores the importance of comprehensive histopathological analysis for accurate diagnosis and appropriate management of pediatric brain tumors.