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Doppler Optical Coherence Tomography of Retinal Circulation
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Lymphography method based on time-autocorrelated optical coherence tomography.

Yi Lian1,2, Tingfeng Li1,2, Nanshou Wu1

  • 1School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006, China.

Biomedical Optics Express
|November 25, 2022
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Summary

We developed a novel lymphography method using time-autocorrelated optical coherence tomography to visualize lymphatic vessels. This non-invasive technique offers high sensitivity for imaging lymph, crucial for diagnosing immune system diseases and metastasis.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Lymphatic System Research

Background:

  • Lymphatic vessels are integral to the immune system, distributing lymph throughout the body.
  • Accurate visualization of lymphatic vessels is critical for diagnosing tumor metastasis and immune-related diseases.
  • Imaging lymph is challenging due to its transparency and slow flow rate.

Purpose of the Study:

  • To present a novel, non-invasive lymphography method for high-sensitivity imaging of lymphatic vessels.
  • To address the limitations of current imaging techniques for lymph.

Main Methods:

  • Utilized time-autocorrelated optical coherence tomography (OCT).
  • Analyzed the minimum value difference of the autocorrelation function of time-varying interference intensity between lymph and surrounding tissues.

Main Results:

  • Achieved non-invasive and high-sensitivity imaging of lymph vessels.
  • Demonstrated the feasibility of the proposed lymphography technique.

Conclusions:

  • The developed time-autocorrelated OCT method enables effective lymphography.
  • This technique holds significant potential for advancing research and treatment of immune system diseases.