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A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound
Xiaomeng Wang1, Xiaoduo Tang1,2,3, Nuo Li1
1Jilin Provincial Key Laboratory of Oral Biomedical Engineering, School and Hospital of Stomatology, Jilin University, Changchun, 130021, P. R. China. jluldw@jlu.edu.cn.
Biomaterials Science
|November 25, 2022
Summary
This study introduces a novel hydrogel patch that promotes partial epithelial-to-mesenchymal transition (EMT) for effective infectious burn wound healing. The patch supports healing by creating a stable microenvironment and reducing inflammation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Cutaneous wound healing aims to restore the epidermal barrier via epithelial-to-mesenchymal transition (EMT).
- Current EMT induction strategies are underdeveloped and carry risks like fibrosis and scarring.
- Controlling EMT is crucial for effective wound repair.
Purpose of the Study:
- To develop a new strategy for infectious burn wound healing using a novel EMT-inducing system.
- To engineer an adhesive hydrogel patch (C&BP-Patch) that facilitates partial EMT for improved epithelial migration.
- To investigate the efficacy of the C&BP-Patch in orchestrating early wound healing processes.
Main Methods:
- Integration of black phosphorus nanosheets (BPNSs), catechol-modified chitosan (CA-CS), and oxidized dextran (Odex) into an adhesive hydrogel patch (C&BP-Patch).
- Utilizing the C&BP-Patch as a bio-sealant to maintain a moist wound microenvironment.
- Leveraging the photothermal effects of the patch for antibacterial action, enhanced microcirculation, and reduced inflammation.
- Investigating the induction of partial EMT via a Snail1-mediated pathway by BPNSs.
Main Results:
- The C&BP-Patch demonstrated remarkable efficacy in healing infectious burn wounds.
- The patch successfully orchestrated hemostasis, inflammation, and proliferation phases of wound healing.
- Fast partial EMT induction was achieved, leading to the restoration of an intact epithelial barrier.
- BPNSs were shown to intrinsically induce partial EMT through the Snail1 pathway.
Conclusions:
- The developed C&BP-Patch offers a promising new strategy for infectious burn wound healing.
- Controlled induction of partial EMT is key to restoring the epithelial barrier effectively.
- The study highlights the potential of biomaterial-based approaches to modulate cellular processes for therapeutic benefits.
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