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Updated: Aug 20, 2025
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Flow Cytometric Characterization of Murine B Cell Development
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Maintenance of Lineage Identity: Lessons from a B Cell
Kalina T Belcheva1, Jayanta Chaudhuri2
1Biochemistry, Cellular and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY; and.
Journal of Immunology (Baltimore, Md. : 1950)
|November 25, 2022
Summary
Maintaining B cell identity relies on transcriptional control. Disrupting this network compromises B cell function, leading to cell plasticity and potential malignant transformation.
Area of Science:
- Immunology
- Cell Biology
- Transcriptional Regulation
Background:
- B cell identity is maintained by a specific transcriptional program that suppresses alternative lineage genes.
- Disruption of the B cell regulatory network can lead to cell fate plasticity and dedifferentiation.
- B lymphocytes serve as a model for understanding lineage stability and cellular plasticity.
Conclusions:
- The B cell lineage's stability highlights the importance of robust regulatory networks.
- Dysregulation of B cell maintenance programs can drive cancer development and treatment resistance.
- Understanding these mechanisms offers insights into cellular plasticity and therapeutic strategies.
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