Bioactive MXene Promoting Angiogenesis and Skeletal Muscle Regeneration through Regulating M2 Polarization and...

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Regenerative Medicine

Background:

• Skeletal muscle repair from severe damage and disease is a significant clinical challenge.
• Two-dimensional titanium carbide (MXene) exhibits unique photoelectromagnetic properties, but its role in skeletal muscle tissue engineering is not well understood.

Purpose of the Study:

• To investigate the antioxidant and anti-inflammatory activities of MXene.
• To evaluate the effects of MXene on skeletal muscle regeneration in vivo and in vitro.

Main Methods:

• In vitro studies on macrophage cells and myoblasts.
• In vivo experiments using rat tibial anterior muscle defect models.

Main Results:

• MXene demonstrated significant antioxidant and anti-inflammatory effects by reducing oxidative stress and promoting M1 to M2 macrophage polarization.
• MXene promoted myoblast differentiation, endothelial cell proliferation, migration, and tube formation.
• In vivo, MXene enhanced angiogenesis, muscle fiber formation, and skeletal muscle regeneration.

Conclusions:

• MXene possesses multifunctional bioactive properties including robust antioxidation, anti-inflammation, and angiogenesis.
• MXene shows potential as a novel biomaterial for enhancing skeletal muscle tissue regeneration.