Related Experiment Video
Updated: Aug 20, 2025
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Cardiovascular diseases in patients after hematopoietic stem cell transplantation: Systematic review and
Azin Alizadehasl1, Nashmil Ghadimi1, Hossein Hosseinifard2
1Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Insights
Cardiovascular disease affects 16.84% of patients after Hematopoietic Stem Cell Transplantation (HSCT). This high prevalence highlights the need for increased attention to cardiovascular complications in HSCT recipients.
Area of Science:
- Cardiology
- Hematology
- Oncology
Background:
- Hematopoietic Stem Cell Transplantation (HSCT) is a crucial treatment for malignancies.
- Cardiovascular complications are a significant concern for HSCT recipients.
- This systematic review and meta-analysis investigates the prevalence of these complications.
Approach:
- A comprehensive literature search was conducted across major databases (PubMed, MEDLINE, Cochrane, Scopus, Web of Science) up to January 2022.
- The Newcastle-Ottawa Scale was employed to assess the quality of included studies.
- 37 articles comprising 30,957 patients were included in the meta-analysis.
Key Points:
- The overall prevalence of cardiovascular disease (CVD) post-HSCT was found to be 16.84%.
- Specific CVD-related complications included Arrhythmias (3.91%), Congestive Heart Failure (3.66%), and Hypertension (17.71%).
- Other examined complications were stroke (0.22%) and mortality (1.53%) in the HSCT population.
Conclusions:
- Cardiovascular disease prevalence after HSCT is notably high.
- These findings underscore the critical need for specialized cardiovascular monitoring and management in HSCT patients.
- Further research and clinical attention are warranted to mitigate these risks.
Background:
Hematopoietic Stem Cell Transplantation (HSCT), is performed to treat many malignancies such as autologous or allogenic. Despite the success of this method in treating patients, - sometimes some HSCT recipients face problems such as cardiovascular complications. Therefore, this systematic review and meta-analysis aimed to evaluate the prevalence of cardiovascular complications in post-transplant patients.
Method:
In order to review the published studies, we examined PubMed, MEDLINE, Cochrane Library, Scopus, and web of science databases from the beginning to the end of January 2022, and we used tools by the Newcastle-Ottawa Scale to evaluate the quality of the studies.
Result:
In this study, 37 articles were included in the meta-analysis and 30,957 patients were examined. Also, the mean age of patients was 35.37 years. Based on the results of the meta-analysis, the prevalence of cardiovascular disease (CVD), was 16.84%. In addition, other complications related to CVD which include Arrhythmias, Congestive Heart Failure (CHF), Hypertension, stroke, and mortality were examined in patients who had hematopoietic stem cell transplantation and the resulting amounts were 3.91%, 3.66, 17.71, 0.22%, and 1.53%, respectively.
Conclusion:
This study showed that the prevalence of cardiovascular disease after hematopoietic stem cell transplantation is high and needs special attention.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
01:01Regulation of Hematopoietic Stem Cells
01:21Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
01:24Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:21Hematopoiesis