Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

7.1K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of non-tobacco nicotine on bone healing: a systematic review and application to total joint arthroplasty.

Journal of orthopaedic surgery and research·2026
Same author

Reply to Letter Regarding "Detecting Artificial Intelligence-Generated Text in Personal Statements of Adult Reconstruction Fellowship Applicants".

The Journal of arthroplasty·2026
Same author

Migration of Primary Total Knee Arthroplasty From Inpatient to Outpatient Facilities in the United States (2019 to 2022): Trends, Demographics, and Comorbidities.

The Journal of arthroplasty·2026
Same author

Reply to the Letter to the Editor Regarding "Increased Waist Circumference Is Associated With Severe Postoperative Medical Complications Following Total Knee Arthroplasty: Understanding Waist Circumference and Relation to Body Mass Index".

The Journal of arthroplasty·2025
Same author

Rare tumour presenting as a cystic lesion in an infant.

BMJ case reports·2025
Same author

Inaccuracies in Orthopaedic Research Fellowship Applications: A Study on Authorship Misrepresentations.

JB & JS open access·2025

Related Experiment Video

Updated: Aug 20, 2025

Reverse Total Shoulder Arthroplasty
10:10

Reverse Total Shoulder Arthroplasty

Published on: July 5, 2011

43.3K

Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.

Zhongming Chen1, Sandeep S Bains1, Daniel Hameed1

  • 1Department of Orthopedic Surgery, Sinai Hospital of Baltimore, Rubin Institute for Advanced Orthopedics, Baltimore, Maryland.

The Journal of Knee Surgery
|November 25, 2022
PubMed
Summary
This summary is machine-generated.

This study analyzed 2021 knee arthroplasty randomized controlled trials (RCTs), finding few focused on prosthetics and none originating from the US. Alternative study designs are suggested for evaluating new knee replacement devices.

More Related Videos

In Vitro Application of a Wireless Sensor in Flexion-Extension Gap Balance of Unicompartmental Knee Arthroplasty
07:33

In Vitro Application of a Wireless Sensor in Flexion-Extension Gap Balance of Unicompartmental Knee Arthroplasty

Published on: May 5, 2023

668
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
09:01

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

11.9K

Related Experiment Videos

Last Updated: Aug 20, 2025

Reverse Total Shoulder Arthroplasty
10:10

Reverse Total Shoulder Arthroplasty

Published on: July 5, 2011

43.3K
In Vitro Application of a Wireless Sensor in Flexion-Extension Gap Balance of Unicompartmental Knee Arthroplasty
07:33

In Vitro Application of a Wireless Sensor in Flexion-Extension Gap Balance of Unicompartmental Knee Arthroplasty

Published on: May 5, 2023

668
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
09:01

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

11.9K

Area of Science:

  • Orthopedic Surgery
  • Biomedical Engineering

Background:

  • Randomized controlled trials (RCTs) are the highest level of scientific evidence.
  • Prospective randomized control trials (PRCTs) are considered the gold standard for intervention efficacy.
  • While numerous RCTs exist for knee arthroplasty, few focus on prosthetic devices.

Purpose of the Study:

  • To analyze the landscape of knee arthroplasty RCTs published in 2021.
  • To categorize studies by topic, country of origin, sample size, and follow-up status.
  • To specifically examine RCTs related to prosthetic design and implantation.

Main Methods:

  • PubMed search for "knee arthroplasty" and "RCT" between January 1 and December 24, 2021.
  • Categorization of studies by topic (rehabilitation, pain control, blood loss, devices/prostheses, etc.).
  • Subcategorization by country of origin, sample size, and follow-up status, with a focus on prosthetic studies.

Main Results:

  • Out of 197 knee arthroplasty RCTs in 2021, 26 (13.2%) focused on prosthetic design and implantation.
  • Only 15% of all knee arthroplasty RCTs were from the US; none of the prosthetic studies were US-based.
  • Prosthetic studies had a smaller mean sample size (86±54) and a higher follow-up rate (23%) compared to overall RCTs.

Conclusions:

  • The field of knee arthroplasty is rapidly advancing, particularly in prosthetics and techniques.
  • There is a notable lack of US-based prospective RCTs specifically evaluating prosthetic devices.
  • Database and registry analyses are recommended as complementary study designs for evaluating new knee arthroplasty prostheses and techniques.