AGE-DEPENDENT IMMUNE STATUS CHANGES IN CHRONIC PANCREATITIS PATIENTS

The negative consequences of constant stress exposure in patients with chronic pancreatitis (CP) develop an immune deficiency, which also depends on the nature of the body's immune response, which may vary at different ages.; The aim of the study - to study and analyze the state of the immune system of patients with chronic pancreatitis in the age aspect.; We examined the immune system (IS) of 161 patients with CP aged 21 to 78 years, mean age - (58.17±2.46) years, which were divided according to biological age into three groups: up to 45 years (54 patients), from 46 to 65 years (76 subjects), older than 65 years (31 patients). The following indicators of immunity were studied: the number of the total population of T-lymphocytes (CD3), B-cells (CD72), subpopulations of T-helpers/inducers (CD4) and T-suppressors/killers (CD8), natural killers (CD16), which determined in a cytotoxic test using monoclonal antibodies of classes CD3, CD4, CD8, CD16, CD72 by enzyme-linked immunosorbent assay according to the level of expression of membrane antigens.; Secondary immunodeficiency by T-suppressor type, insignificant nonspecific activation of humoral immunity, and decrease in complement activity was established in patients with CP. Changes in the T-cell level of immunity due to the probable decrease in the level of CD3, CD4, CD8, CD16, and CD 72 in young patients by 44.8; 36.1; 24.4; 32.2, and 18.4 %%, respectively (p<0.001); in middle age, immune deficiency deepened, which was manifested by a decrease in these indicators by 54.6; 37.2; 29.9; 41.4 and 25.6 %%, respectively (p<0.001); in patients over 65 years of age, probable T-lymphocytopenia was determined by 66.4; 47.8; 37.7; 70.8; 41.5 %% (p<0.001) compared with the control group.; Based on the regression-correlation analysis, it is proved that the age of patients, duration of CP, level of fecal α-elastase, and structural state of the pancreas according to ultrasound criteria are reliable predictors of immunodeficiency in CP.