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Related Experiment Video

Updated: Aug 20, 2025

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Sentinel Lymph Node Mapping and Biopsy in Cats with Solid Malignancies: An Explorative Study.

Lavinia Elena Chiti1, Elisa Maria Gariboldi2, Damiano Stefanello2

  • 1Clinic for Smal Animals Surgery, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.

Animals : an Open Access Journal From MDPI
|November 26, 2022
PubMed
Summary
This summary is machine-generated.

Sentinel lymph node biopsy (SLNB) is feasible and safe in cats with solid tumors. This technique, using near-infrared fluorescent lymphography or lymphoscintigraphy, aids accurate cancer staging, particularly for mast cell tumors.

Keywords:
cancercatfelinesentinel lymph nodestaging

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Area of Science:

  • Veterinary oncology
  • Surgical oncology
  • Diagnostic imaging

Background:

  • Sentinel lymph node biopsy (SLNB) is crucial for cancer staging in dogs but lacks data in cats.
  • Accurate staging is vital for effective treatment planning in feline malignancies.

Purpose of the Study:

  • To evaluate the feasibility and detection rates of SLNB in cats with solid tumors.
  • To assess the utility of lymphoscintigraphy and near-infrared fluorescent lymphography (NIRF-L) for SLNB in cats.
  • To determine the complication rate and diagnostic yield of SLNB in feline cancer patients.

Main Methods:

  • Retrospective analysis of 12 cats with 14 solid tumors undergoing curative-intent surgery and SLNB.
  • SLNB was guided by lymphoscintigraphy and/or NIRF-L.
  • Data collected included mapping technique, SLN location and number, correspondence with regional lymph nodes (RLNs), and SLN histopathology.

Main Results:

  • 100% detection rate for SLNB using both lymphoscintigraphy and NIRF-L.
  • SLNs did not fully correspond to RLNs in 71.4% of cases; multiple SLNs were excised in 9/14 tumors.
  • Metastases were identified in 41.7% of cats, exclusively in those with mast cell tumors (MCT).
  • No complications related to SLNB were recorded.

Conclusions:

  • SLNB guided by NIRF-L or lymphoscintigraphy is a feasible and safe procedure in cats with solid tumors.
  • This technique is recommended for accurate tumor staging in cats, especially for mast cell tumors.
  • SLNB provides critical staging information that may differ from traditional regional lymph node assessment.