Related Experiment Video
Updated: Aug 20, 2025

Optimization of Processing of Tiebangchui with Highland Barley Wine Based on the Box-Behnken Design Combined with the Entropy Method
Published on: May 19, 2023
Parameter Estimation of Dynamic Beer Fermentation Models
Jesús Miguel Zamudio Lara1,2, Laurent Dewasme1, Héctor Hernández Escoto2
1Systèmes, Estimation, Commande et Optimisation, Université de Mons, 7000 Mons, Belgium.
This study introduces two dynamic beer fermentation models, validated with experimental data. These models enhance monitoring and control by predicting fermentation dynamics, optimizing the brewing process.
Area of Science:
- Biotechnology
- Chemical Engineering
- Food Science
Background:
- Beer fermentation is a complex biochemical process crucial for product quality.
- Accurate dynamic models are needed for effective process monitoring and control.
- Existing models may lack the predictive power for advanced control strategies.
Purpose of the Study:
- To develop and validate two dynamic models for beer fermentation.
- To estimate model parameters using comprehensive experimental data.
- To assess the models' predictive capabilities for monitoring and control applications.
Main Methods:
- Development of two distinct dynamic mathematical models for beer fermentation.
- Parameter estimation using off-line (biomass, sugar, ethanol, vicinal diketones) and on-line (temperature, ethanol, CO2 exhaust) measurements.
- Structural identifiability analysis to ensure model parameter uniqueness.
- Cross-validation to evaluate model predictive performance.
Main Results:
- Successful estimation of model parameters using diverse experimental data.
- Demonstrated structural identifiability of the proposed models.
- Validated predictive capability of the dynamic models through cross-validation.
- Identified potential applications in advanced process control.
Conclusions:
- The proposed dynamic models offer a robust framework for understanding beer fermentation.
- These models can be utilized as predictors in receding-horizon observers and controllers.
- The study opens new perspectives for real-time monitoring and enhanced control of fermentation processes.
Related Concept Videos
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Microbial Growth Measurement: Indirect Methods
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Mechanistic Models: Compartment Models in Individual and Population Analysis

