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Related Concept Videos

Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
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In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
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In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
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Development of Flow-Through Cell Dissolution Method for In Situ Visualization of Dissolution Processes in Solid

Niloofar Moazami Goudarzi1,2, Aseel Samaro3, Chris Vervaet3

  • 1Department of Physics and Astronomy, Radiation Physics, Ghent University, Proeftuinstraat 86/N12, 9000 Gent, Belgium.

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Summary

This study introduces X-ray tomography to visualize drug dissolution in 3D printed tablets. This novel method enhances understanding of drug release mechanisms and dosage form design.

Keywords:
3D printingcontrast agentdissolutionflow-through cell methodsustained releaseμCT

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Imaging Technology

Background:

  • Understanding drug release dynamics is crucial for designing effective pharmaceutical dosage forms.
  • Current methods for studying dissolution lack detailed visualization of internal structural changes.
  • 3D printed tablets offer customizable drug delivery but require advanced characterization techniques.

Purpose of the Study:

  • To develop and validate an X-ray tomography-based approach for visualizing the pore-scale dynamics during pharmaceutical dosage form dissolution.
  • To analyze the dissolution behavior of a polycaprolactone-based sustained-release 3D printed tablet.
  • To investigate the influence of flow rate on drug release and validate the technique against standard dissolution tests.

Main Methods:

  • Development of a flow-through cell dissolution apparatus compatible with X-ray tomography.
  • Utilizing cesium chloride (CsCl) as a contrast agent for enhanced imaging.
  • Studying the dissolution of a Capa® (polycaprolactone)-based 3D printed tablet.
  • Real-time monitoring of solution ingress and internal structural changes.

Main Results:

  • The X-ray tomography method successfully visualized the dynamic structural changes during dissolution at the pore scale.
  • A flow rate of 16 mL/min was identified as optimal for studying the dissolution of the 3D printed tablet.
  • The results from the novel technique showed good agreement with standard in vitro dissolution tests (f2 = 77%).
  • Real-time tracking of solution ingress into the tablet was achieved.

Conclusions:

  • X-ray tomography provides a powerful, non-destructive tool for visualizing and analyzing the dissolution process of pharmaceutical dosage forms.
  • This technique offers valuable insights into drug release mechanisms, aiding in the design of advanced drug delivery systems.
  • The developed method is suitable for characterizing 3D printed tablets and other complex pharmaceutical formulations.