A novel sensor system to detect cerebral hemorrhage in rabbits through MIPS

Magnetic-induction phase shift (MIPS) was rarely used in vivo and clinically because of low sensitivity and nonquantitative detection. The conventional single excitation coil and single detection coil (single coil-coil) generates divergent excitation magnetic field, resulting in different sensitivity of different object positions.

To improve the sensitivity and linearity of MIPS and object volume to realize quantitative detection, a novel sensor system was proposed.

The novel sensor system adopted uniform rotating magnetic field replacing the divergent magnetic field for the first time integrated with primary field cancellation. The uniform rotating magnetic field was generated by a birdcage coil excited by two orthogonal current; the primary field cancellation was realized by a specially arranged solenoid receiver coil installed co-axially with the birdcage coil detecting the z, not x and y-component of the secondary magnetic field.

The saltwater simulation experiment showed that MIPS changed high linearity with the injection volume of all four different conductivity solutions. The experimental results of rabbit cerebral hemorrhage (CH) revealed that with injected blood volume increased to 3 ml, the MIPS linearly decreased to -1.916°, which was 5.5 times higher than that of the single coil-coil method.

Compared with the single coil-coil method, this novel detection system was more sensitive and linearly correlated for the detection of bleeding volume. It provided the probability of quantitative detection of the CH volume and a series of brain-content diseases.