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Transient Receptor Potential Vanilloid 4: a Double-Edged Sword in the Central Nervous System

Meng-Liu Zeng^1,2, Shuo Kong¹, Tao-Xiang Chen¹

¹Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Donghu Rd185#, Wuhan, 430071, Hubei, China.

Molecular Neurobiology

|November 26, 2022

Abstract:

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel that can be activated by diverse stimuli, such as heat, mechanical force, hypo-osmolarity, and arachidonic acid metabolites. TRPV4 is widely expressed in the central nervous system (CNS) and participates in many significant physiological processes. However, accumulative evidence has suggested that deficiency, abnormal expression or distribution, and overactivation of TRPV4 are involved in pathological processes of multiple neurological diseases. Here, we review the latest studies concerning the known features of this channel, including its expression, structure, and its physiological and pathological roles in the CNS, proposing an emerging therapeutic strategy for CNS diseases.

Keywords:

Central nervous system Pathological function Physiological function Transient receptor potential vanilloid 4

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