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Mildly Elevated Pulmonary Hypertension: Gray Zone or Already a Disease?
Alberto M Marra1, Umberto Attanasio2, Alessandra Cuomo2
1Department of Translational Medical Sciences, Federico II University, Naples, Italy; Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
The definition of pulmonary hypertension (PH) now includes lower mean pulmonary arterial pressure (mPAP) thresholds. This review examines the clinical impact of this updated PH definition, focusing on mildly elevated pressure ranges.
Area of Science:
- Cardiology
- Pulmonology
- Medical Diagnostics
Background:
- Pulmonary hypertension (PH) diagnosis relies on mean pulmonary arterial pressure (mPAP) measurements.
- The sixth World Symposium on Pulmonary Hypertension revised the diagnostic criteria for PH.
Purpose of the Study:
- To analyze the impact of the new PH definition with a lowered mPAP threshold.
- To review literature on patients with mPAP between 21-24 mmHg (mildly elevated PH).
- To discuss clinical practice implications and future perspectives of the revised PH definition.
Main Methods:
- Literature review of recent scientific data.
- Analysis of studies concerning subjects with mPAP between 21 and 24 mmHg.
- Discussion of clinical practice and future research directions.
Main Results:
- The new definition lowers the diagnostic threshold for PH.
- Focus on the 'mildly elevated PH' group (mPAP 21-24 mmHg) provides new insights.
- The revised threshold impacts clinical practice and diagnostic approaches.
Conclusions:
- The updated PH definition necessitates re-evaluation of diagnostic and treatment strategies.
- Understanding outcomes in the mildly elevated PH range is crucial.
- This review highlights evolving perspectives in pulmonary hypertension management.
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