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Measurably recombining malaria parasites.

Flavia Camponovo1, Caroline O Buckee1, Aimee R Taylor2

  • 1Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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|November 26, 2022
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Genomic epidemiology is key for tracking diseases. This study introduces "measurably recombining parasites" for sexually reproducing pathogens like malaria, enhancing genomic epidemiology for public health.

Keywords:
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Area of Science:

  • Genomic epidemiology
  • Parasitology
  • Evolutionary biology

Background:

  • Genomic epidemiology has been instrumental in understanding viral pathogens.
  • Applying genomic epidemiology to eukaryotic pathogens, like the malaria parasite, presents unique challenges due to sexual recombination.
  • The concept of 'measurably mutating pathogens' used for viruses does not directly apply to sexually recombining parasites.

Purpose of the Study:

  • To introduce the concept of "measurably recombining malaria parasites" as a framework for malaria genomic epidemiology.
  • To promote a unifying theoretical foundation for studying sexually recombining pathogens.
  • To enhance the application of genomic epidemiology for malaria control and other related diseases.

Main Methods:

  • Conceptual framework development.
  • Theoretical modeling of recombination in pathogens.
  • Comparative analysis with viral genomic epidemiology and phylodynamics.

Main Results:

  • A new concept, "measurably recombining parasites," is proposed for sexually reproducing pathogens.
  • This framework is analogous to "measurably mutating pathogens" used for viruses.
  • It provides a basis for developing inferential tools for malaria genomic epidemiology.

Conclusions:

  • The concept of measurably recombining parasites offers a unifying theoretical framework for malaria genomic epidemiology.
  • This approach is expected to guide practical research and improve public health strategies for malaria.
  • The framework has potential applications for other sexually recombining pathogens.